DANVILLE, Ky. - At odds early and often, Joe Biden and Republican Paul Ryan squabbled over the economy, taxes, Medicare and more Thursday night in a contentious, interruption-filled debate. "That is a bunch of malarkey," the vice president retorted after a particularly tough Ryan attack on the administration's foreign policy.
"Not a single thing he said is accurate," Democrat Biden declared after Ryan said U.S. Ambassador Chris Stevens had been denied sufficient security by administration officials. Stevens died in a terrorist attack on the U.S. Consulate in Benghazi on Sept. 11.
Both men seemed primed for a showdown from their opening moments on stage, and neither seemed willing to let the other one have the final word.
"I know you're under a lot of duress to make up for lost ground, but I think people would be better served if we don't interrupt each other," Ryan said to his older rival at one point. But both continued to do so - and interrupted moderator Martha Raddatz of ABC as well.
The debate took place a little more than a week after President Barack Obama and Republican challenger Mitt Romney met in the first of their three debates - an encounter that has fueled a Republican comeback in opinion polls.
With Democrats eager for Biden to show the spark the president lacked, he did so.
Unprompted, he brought up the video in which Romney had said 47 percent of Americans pay no federal income tax, view themselves as victims and do not take responsibility for their own lives.
"It's about time they take responsibility" instead of signing pledges to avoid raising taxes, Biden said - of Romney, Ryan and the Republicans.
But Ryan quickly turned to dreary economic statistics - 23 million are struggling to work, he said, and 15 percent of the country is living in poverty. "This is not what a real recovery looks like."
Medicare was a flashpoint, as well. Ryan said Obama's health care plan had diverted $716 billion from the program for seniors and created a new board that could deny care to patients who need it.
Democrats "haven't put a credible solution on the table," he said. "They'll tell you about vouchers. They'll say all these things to try to scare people."
Romney has gained ground in national and battleground-state surveys in the week since he shared a stage with the president, and even Obama has conceded he performed poorly.
Asked directly when they could reduce unemployment to 6 percent from the current 7.8 percent, neither man answered directly.
Instead, Biden repeated the president's contention that the nation is moving in the right direction, while Ryan repeated the Republican view that economic struggle persists even though Democrats had control of both houses of Congress during the first two years of Obama's term.
"Where are the 5 million green jobs" we were told would be created? Ryan said to Biden.
Republicans and Democrats alike have said in recent days the race now approximates the competitive situation in place before the two political conventions. The two men are generally separated by a point or two in national public opinion polls and in several battleground states, with Obama holding a slender lead in Ohio and Wisconsin.
Both men campaigned during the day as their political partners prepped for their moment on the debate stage.
Mocking recent changes in Romney's rhetoric, Obama told a Miami rally on Thursday, "After running for more than a year in which he called himself severely conservative, Mitt Romney is trying to convince you that he was severely kidding."
Romney visited with 93-year-old Billy Graham in North Carolina before speaking to an evening rally in Asheville, N.C. "Prayer is the most helpful thing you can do for me," he told the evangelist.
For Biden, Thursday night's debate was his first since the 2008 campaign, when he shared a stage with Sarah Palin, then John McCain's running mate.
Ryan spars frequently with Democrats during debates on legislation on the House floor and in the House Budget Committee, which he chairs, but not in a one-on-one encounter covering 90 minutes and a virtually unlimited range of topics.
For all their differences, the two men shared a common objective, to advance the cause of their tickets in a close race for the presidency - and avoid a gaffe that might forever seal their place in the history of debates.
Romney's choice of Ryan as running mate over the summer cheered conservatives in the House, many of whom regard him as their leader on budget and economic issues. The seven-term lawmaker has authored a pair of deficit-reducing budgets in the past two years that call for spending cuts and changes in Medicare, blueprints that Republicans passed through the House and Obama and his allies in Congress frequently criticize.
He also champions a no-tax increase approach to economic policy.
As a senator before becoming vice president, Biden was chairman of the Foreign Relations and Judiciary committees, and he has long experience in national security issues. More recently, he was Obama's point man in arduous, ultimately unsuccessful negotiations with Republicans on steps to cut the deficit.
Both Ryan and Biden held extensive rehearsals, with stand-ins for their opponents.
Biden turned to Rep. Chris Van Hollen, D-Md., who is well-versed in Ryan's policy views from his tenure as senior Democrat on the Budget Committee.
Ryan's foil in rehearsal was former Solicitor General Ted Olson, a skillful courtroom advocate.
Martha Raddatz of ABC News had moderator duties.
After they meet next week in Hempstead, N.Y., Obama and Romney will have one more debate, Oct. 22 in Boca Raton, Fla.
Associated Press writers Philip Elliott in Kentucky, Ken Thomas in Florida and Kasie Hunt in North Carolina contributed. Espo reported from Washington.
Copyright 2012 The Associated Press.