Two people were injured and a portion of Lycoming Mall Road was closed for more than three hours following a four-vehicle crash in Fairfield Township about 5:30 p.m. Wednesday.
The two who were hurt were taken by ambulance to the Williamsport Regional Medical Center. Their identities were not available on Wednesday.
Emergency responders described the condition of the road as "a sheet of ice."
After a pickup truck and a car collided head-on, two other vehicles slid off the road to avoid the collision, which occurred in the 4800 block.
Volunteer fire police closed the thoroughfare from Fairfield to Cemetery roads until the damaged vehicles were removed.
Shortly after the crash, a minor crash occurred in the 3600 block of Lycoming Mall Road, where a motorist slid off the road and struck a guardrail. No one was injured.