Ajayi ties NFL record with 2nd straight 200-yard game

San Francisco 49ers tight end Vance McDonald, left, cannot catch a pass over Tampa Bay Buccaneers outside linebacker Lavonte David, right, during the second half of an NFL football game in Santa Clara, Calif., Sunday, Oct. 23, 2016. (AP Photo/Marcio Jose Sanchez)

San Francisco 49ers tight end Vance McDonald, left, cannot catch a pass over Tampa Bay Buccaneers outside linebacker Lavonte David, right, during the second half of an NFL football game in Santa Clara, Calif., Sunday, Oct. 23, 2016. (AP Photo/Marcio Jose Sanchez)

MIAMI GARDENS, Fla. — Jay Ajayi tied an NFL record by surpassing 200 yards rushing for the second game in a row as the Miami Dolphins beat the Buffalo Bills, 28-25, Sunday.

Ajayi rushed for 214 yards in 29 carries after totaling 204 yards a week earlier in a win over Pittsburgh. He scored on a 4-yard run, and busted a 53-yarder when the Dolphins were pinned at their 3 and trailing in the fourth quarter.

The Dolphins (3-4) used an extra lineman much of the time to clear big holes for Ajayi, who tied the NFL record for consecutive 200-yard games held by O.J. Simpson, Earl Campbell and Ricky Williams.

Miami overcame an 11-point deficit with 16 minutes left to end a four-game winning streak by the Bills (4-3) and beat them for only the second time in their past seven meetings.

Buffalo RB LeSean McCoy, ranked second in the NFL in rushing, started, but totaled only 11 yards in eight carries before departing with a hamstring problem.

CHARGERS 33, FLACONS 30

ATLANTA — Josh Lambo’s 42-yard field goal in overtime gave San Diego its first road win of the year as the Chargers rallied from a 17-point deficit.

The Chargers (3-4) trailed 27-10 in the second quarter. They had lost 11 of their past 12 road games.

Linebacker Denzel Perryman delivered two key plays late in the game. Perryman’s interception of Matt Ryan’s pass for Julio Jones set up Lambo’s tying 33-yard field goal with 18 seconds remaining in regulation.

Perryman’s fourth-and-1 stop on running back Devonta Freeman gave San Diego the ball at Atlanta’s 43 for the Chargers’ winning drive. Perryman grabbed Freeman’s feet behind the line for the key tackle on the Falcons’ gamble.

CHIEFS 27, SAINTS 21

KANSAS CITY, Mo. — Alex Smith threw two touchdown passes in another efficient outing, and Daniel Sorensen returned an interception of Drew Brees for another touchdown.

Spencer Ware ran for 77 yards to go with his 46-yard touchdown reception, and Tyreek Hill made an acrobatic 38-yard TD catch to help the Chiefs (4-2) win their ninth straight at home.

Brees got the Saints (2-4) within 24-21 with his touchdown pass to Brandon Coleman with 2:33 left, but the ensuing onside kick went out of bounds. Kansas City added a 41-yard field goal, and the Saints could do nothing in the final 28 seconds.

Brees finished with 367 yards and three TD passes.

RAIDERS 33, JAGUARS 16

JACKSONVILLE, Fla. — Latavius Murray scored twice in his return from turf toe, and the Raiders gave coach Jack Del Rio a victory against his former team.

Murray, who missed the past two games, finished with 59 yards on 18 carries. Michael Crabtree caught eight passes for 96 yards and a touchdown from Derek Carr, Sebastian Janikowski kicked four field goals, and the Raiders played the kind of defense they’ve been looking for all season.

The result was the team’s most complete win of the season. Oakland improved to 4-0 on the road and moved to 5-2 for the first time since 2001.

The Jaguars (2-4), meanwhile, dropped a third straight at EverBank Field and added more speculation about the future of coach Gus Bradley.    Jacksonville fell to 14-40 during Bradley’s four seasons, and the latest loss was filled with poor execution on both sides of the ball and a lack of discipline down the stretch.

LIONS 20, REDSKINS 17

DETROIT — Matthew Stafford threw a go-ahead, 18-yard touchdown pass to Anquan Boldin with 16 seconds left.

The Lions (4-3) extended their winning streak to three games. The Redskins (4-3) had won four straight.

Stafford, who set up game-winning kicks in the previous two games, led his team to another win in the 100th game of his career. He was 18 of 29 for 266 yards, one TD and no turnovers.

Kirk Cousins scored a go-ahead TD on a 19-yard run with 1:05 left.

The Redskins, though, failed to stop Stafford from throwing or running on his last possession and could not overcome mistakes that included turnovers, a missed field goal and penalties.

GIANTS 17, RAMS 10

LONDON — The Giants capitalized on four interceptions of Case Keenum in the first NFL game played at London’s home of English rugby, a sold-out and raucous Twickenham Stadium.

Keenum, coming off the best start of his career, had the Rams at the Giants’ 15-yard line with 50 seconds left when he lobbed a pass in the left corner of the end zone that Dominique Rodgers-Cromartie easily picked off. Keenum’s intended target, Brian Quick, failed to get the quarterback’s audible and cut off his route early.

Keenum, who finished 32 of 53 for 291 yards and one touchdown, has thrown an interception on the Rams’ final offensive play of the last three games. That likely will fuel debate on a potential quarterback change to overall No. 1 draft pick Jared Goff.

Landon Collins returned his first of two picks 44 yards for a second-quarter touchdown, and Dominique Rodgers-Cromartie also had two interceptions.

BENGALS 31, BROWNS 17

CINCINNATI — A.J. Green’s one-handed catch in the middle of an end zone scrum highlighted Cincinnati’s day full of big plays.

Green’s 48-yard touchdown catch on the final play of the first half helped the Bengals (3-4) regain their footing in the injury-depleted AFC North. The defending division champions piled up their most points since they beat the Browns 37-3 last December. Jeremy Hill had a 74-yard touchdown run as part of his 168-yard effort, the best by a Bengals running back in seven years.

The Browns (0-7) extended their worst start since 1999, when they were a first-year expansion team. The NFL’s only winless team also lost yet another quarterback — the theme of their season. Cody Kessler got hit hard while throwing a shovel pass in the second quarter, then went to the locker for a concussion evaluation and was ruled out. That left the offense in the hands of undrafted rookie Kevin Hogan, the Browns’ sixth quarterback of the season.

COLTS 34, TITANS 26

NASHVILLE, Tenn. — Andrew Luck threw a 7-yard touchdown pass to Jack Doyle with 1:55 left to put Indianapolis ahead to stay, and the Colts rallied to beat the Titans for their 10th straight win against their AFC South rival.

The Colts (3-4) came in having lost two of three, including blowing a 14-point lead in an overtime loss last week at Houston. But Luck he improved to 8-0 against the Titans with yet another comeback win. He finished with 353 yards passing and three TDs, the last after Tennessee went up 23-20.

T.Y. Hilton caught seven passes for 133 yards, including a 37-yard TD. The Colts shook off 12 penalties for 131 yards in pulling out their 15th win in 16 games against Tennessee.

The Titans (3-4) saw their two-game winning string end.

Colts kicker Adam Vinatieri kicked a pair of field goals, and the second, a 33-yarder with 3:46 left in the third quarter gave him an NFL record 43 consecutive field goals made.

JETS 24, RAVENS 16

EAST RUTHERFORD, N.J. — Ryan Fitzpatrick replaced an injured Geno Smith and led the Jets on three scoring drives, and a rejuvenated defense came up with two rare interceptions.

Fitzpatrick came in for Smith in the second quarter and led the Jets on a go-ahead drive capped by a 13-yard touchdown catch by Matt Forte. Fitzpatrick finished 9 of 14 for 120 yards and a touchdown as the Jets (2-5) snapped a four-game losing streak.

Smith injured his right knee while taking a sack from Baltimore’s Matthew Judon. Fitzpatrick was efficient after losing his job earlier in the week.

Joe Flacco started for Baltimore (3-4), loser of four in a row, after being questionable with a sore shoulder. He went a team-record 176 consecutive throws without an interception before Buster Skrine picked off his pass in the third quarter.

BUCCANEERS 34, 49ERS 17

SANTA CLARA, Calif. — Jameis Winston threw three touchdown passes and Jacquizz Rodgers ran for 154 yards.

The Bucs (3-3) fell behind by 14 points early before scoring 27 straight to deal the Niners (1-6) their sixth straight loss for San Francisco’s longest losing streak since 2008.

Mike Evans caught eight passes for 96 yards and two touchdowns, Russell Shepard scored on a 19-yard pass from Winston, and Peyton Barber iced the game with a 44-yard touchdown run in the fourth quarter to help Tampa Bay win its second straight game around its bye week.

Colin Kaepernick struggled in his second start of the season for the 49ers, going 16 for 34 for 143 yards and turning the ball over twice after kneeling once again for the national anthem.